Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is often an impurity associated with bortezomib, a proteasome inhibitor used in the treatment method of a number of myeloma. Its synthesis or research is crucial for guaranteeing the purity and safety on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor within the synthesis of abiraterone acetate, a drug Utilized in the treatment method of prostate most cancers by inhibiting androgen output.
Imatinib Intermediate (CAS NO. 152460-10-1): A crucial compound from the synthesis of imatinib, a drug that targets specific varieties of cancer, like Long-term myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats various cancers like breast, lung, and prostate cancer.
2. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are generally intermediates during the synthesis of gemcitabine, an anti-most cancers drug. Their review is essential for optimizing the manufacturing procedure and making certain large purity.
Lapatinib Intermediate (CAS NO. 231278-84-five): Lapatinib is utilized to deal with breast most cancers, and these intermediates are linked to its production.
Fulvestrant Intermediates: Fulvestrant is undoubtedly an estrogen receptor antagonist Employed in the treatment of breast cancer. Different intermediates assist in the synthesis of the drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-16-9): This intermediate is Utilized in the synthesis of paclitaxel, a chemotherapy drug helpful in treating cancers including ovarian, breast, and lung cancer.
3. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Utilized in the cure of colorectal most cancers and compact cell lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-eighty two-nine): 2 This compound is involved with the synthesis of adamantane derivatives, that have various applications, like antiviral Houses.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral drug for style two diabetic issues that inhibits the enzyme DPP-four to manage blood sugar degrees.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-1): This compound is associated with the synthesis of various gluconic acid derivatives, which can be Utilized in foods, pharmaceutical, and industrial programs.
Canagliflozin Intermediate 2: A precursor in the synthesis of 5-dibenzoate(T6) canagliflozin, a medication utilized to deal with style two diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).